On Saturday, April 4, Archbishop Weisenburger led the Archdiocese of Detroit in the solemn celebration of Christ's victory of sin and death during the Easter Vigil in the holy night at the Cathedral of the Most Blessed Sacrament in Detroit. The most solemn liturgy of the Church's year, the Mass began in darkness, illuminated only by the Easter fire, and ended with the joyous celebration of the Eucharist, complete with new Catholics welcomed into the Church via baptism and confirmation.

On Good Friday, April 3, Archbishop Weisenburger led Detroit's faithful in somber prayer as the Archdiocese of Detroit remembered Christ's passion and death on the cross. On the only day of the Church's liturgical year without a Mass, members of the faithful approached to venerate the sacred wood of the Cross, as the tabernacle remained open and empty, a reminder of the absence of Christ in anticipation of the glory of the Resurrection on Easter Sunday.

On Holy Thursday, April 2, Archbishop Weisenburger led Detroit's faithful in the celebration of the Mass of the Lord's Supper, which commemorates Christ's institution of the Holy Eucharist and the sacred priesthood on the night before his death. In imitation of Jesus' washing the feet of his apostles, Archbishop Weisenburger washed the feet of parishioners at the Cathedral of the Most Blessed Sacrament before leading the faithful in somber silence, keeping watch and praying with Christ at the altar of repose.

On Holy Thursday, April 2, Archbishop Weisenburger celebrated the annual Chrism Mass with Detroit's priests at the Cathedral of the Most Blessed Sacrament in Detroit. One of the most solemn Masses of the year, the Chrism Mass is an occasion for priests across the archdiocese to renew their vows and receive the sacred oils that will be used throughout the year during baptisms, confirmations, ordinations and anointings.

On Sunday, March 29, Archbishop Weisenburger celebrated Mass on Palm Sunday of the Lord's Passion to mark the start of the solemn Holy Week liturgies at the Cathedral of the Most Blessed Sacrament in Detroit. Like Masses celebrated across the Archdiocese of Detroit, the cathedral's liturgy began outside the church with the blessing of the palms before proceeding into the sanctuary. The Mass, one of the most solemn of the Church's liturgical year, included the reading of the Gospel account of Jesus' crucifixion and death in preparation for the Sacred Triduum.